Home / News / News / 3-Methylpyridine Introduction

Hot News

Contact Us

 Fenghui South Road, Dev.Zone of 
High-Tech Ind.,Xi’an, China 710075
 +86-29 8874 5613-828
 : albert@yuanfar.com

3-Methylpyridine Introduction

Views: 0     Author: Site Editor     Publish Time: 2023-09-06      Origin: Site

3-Methylpyridine or 3-picoline, is an organic compound with formula 3-CH3C5H4N. It is one of three isomers of methylpyridine. This colorless liquid is a precursor to pyridine derivatives that have applications in the pharmaceutical and agricultural industries. Like pyridine, 3-methylpyridine is a colorless liquid with a strong odor. It is classified as a weak base.

3-Picoline is a useful precursor to agrochemicals, such as chlorpyrifos. Chlorpyrifos is produced from 3,5,6-trichloro-2-pyridinol, which is generated from 3-picoline by way of cyanopyridine. This conversion involves the ammoxidation of 3-methylpyridine:

3-CH3C5H4N + 1.5 O2+ NH3→ 3-NCC5H4N + 3 H2O

3-Cyanopyridine is also a precursor to 3-pyridinecarboxamide, which is a precursor to pyridinecarbaldehydes:

3-NCC5H3N + [H] + catalyst → 3-HC(O)C5H4N

Pyridinecarbaldehydes are used to make antidotes for poisoning by organophosphate acetylcholinesterase inhibitors.

Pyridine derivatives (including 3-methylpyridine) are environmental contaminants, generally associated with processing fossil fuels, such as oil shale or coal. They are also found in the soluble fractions of crude oil spills. They have also been detected at legacy wood treatment sites. The high water solubility of 3-methyl pyridine increases the potential for the compound to contaminate water sources. 3-methyl pyridine is biodegradable, although it degrades more slowly and volatilize more readily from water samples than either 2-methyl- or 4-methyl-pyridine.

3-Methylpyridine is the main precursor to niacin, one of the B vitamins. Niacin is the generic name for both nicotinic acid and nicotinamide (pyridine 3-carboxylic acid and pyridine 3-carboxylic acid amide). Nicotinic acid was first synthesized in 1867 by oxidative degradation of nicotine. Niacin is also an important food additive for domestic and farm animals; more than 60% of the niacin produced is consumed by poultry, swine, ruminants, fish, and pets. Along with its use as an essential vitamin, niacin is also a precursor to many of commercial compounds including cancer drugs, antibacterial agents, and pesticides. Approximately 10,000,000 kilograms of niacin are produced annually worldwide.

4-Niacin is prepared by hydrolysis of nicotinonitrile, which, as described above, is generated by oxidation of 3-picoline. Oxidation can be effected by air, but ammoxidation is more efficient. The catalysts used in the reaction above are derived from the oxides of antimony, vanadium, and titanium. New “greener” catalysts are being tested using manganese-substituted aluminophosphates that use acetyl peroxyborate as non-corrosive oxidant. The use of this catalyst/oxidizer combination is greener because it does not produce nitrogen oxides as do traditional ammoxidations.

YUANFAR CHEMICAL have been engaged in chemical business since 2001, and has our own factories  manufacturing hydrazine product

Quick Link

Contact Us

 +86-29 8860 8992
 : albert@yuanfar.com
 Fenghui South Road, Dev.Zone of 
High-Tech Ind.,Xi’an, China 710075
Send Message