Views: 1 Author: Site Editor Publish Time: 2022-12-07 Origin: Site
1.Ethyl vinyl ether is used as chemical intermediate,spice and lubricant additive.Used as softener,binder,paint,leather paint,textile surface treatment agent, synthetic rubber modifier and intermediate for manufacturing sulfadiazine.
2.Vinyl ether paralyzes the central nervous system,and its anesthetic effect is stronger than that of ether,so it is used medicinally as an anesthetic and analgesic. It is also an intermediate of fine chemicals and can be used in the production of drugs such as sulfadiazine,disinfectant glutaraldehyde,polymers,coatings,etc.It can also be used to produce spices and lubricating oil additives.
3.Ethyl vinyl ether is mainly used as the protective group of hydroxyl,vinyl transfer agent, and participate in cycloaddition reaction in organic synthesis.Among the numerous hydroxyl protecting groups,ethyl vinyl ether is formed with hydroxyl α- Ethoxyethyl ether (EE) is one of the most common and convenient protecting groups.This reaction generally requires a strong acid catalyst,TFA and TsOH can be used for this purpose,and PPTS is the most commonly used.The reaction is usually completed by stirring for several hours at room temperature,and the product yield is more than 95% in most cases (Formula 1).The EE protecting group can easily complete the deprotection reaction under acidic conditions,PPTS EtOH and aq HCl MeOH is a recommended method Under the action of mercury acetate derivative catalyst,ethyl vinyl ether and hydroxyl undergo vinyl transfer reaction to generate corresponding vinyl ether product.If metal palladium catalyst is used,the use of metal mercury catalyst can be effectively avoided.This reaction is more meaningful because the product can undergo further condensation reaction or olefin metathesis.The vinyl transfer reaction between ethyl vinyl ether and allylic hydroxyl generates corresponding vinyl ether products,and the reaction is usually completed under the catalysis of mercury acetate.Heating the product in toluene or xylene can induce the corresponding Claisen rearrangement,which makes the reaction have important synthetic value.Generally,these two steps of reaction can be completed under the condition of "one pot boiling".In the presence of Lewis acid catalyst,ethyl vinyl ether can also undergo corresponding cyclization reaction.