Learn details of the wide use of acetonitrile
Views: 12 Author: Site Editor Publish Time: 2022-11-09 Origin: Site
Use of acetonitrile
Acetonitrile is mainly used as solvent.For example,it can be used as solvent for butadiene extraction,solvent for synthetic fiber and solvent for some special coatings.Solvent used in petroleum industry to remove tar,phenol and other substances from petroleum hydrocarbons.It is used as solvent for extracting fatty acids from animal and vegetable oils in the oil industry,and as reaction medium for recrystallization of steroid drugs in medicine.When polar solvent with high dielectric constant is needed,binary azeotropic mixture formed by acetonitrile and water is often used:containing 84% acetonitrile,boiling point 76 ℃.Acetonitrile is an intermediate of medicine (vitamin B1) and spices,and is the raw material for manufacturing triazine nitrogen fertilizer synergist.It is also used as a denaturant for alcohol.In addition,it can also be used to synthesize ethylamine,acetic acid,etc.And has many uses in fabric dyeing and lighting industries.
Laboratory use of ACN 
Acetonitrile is a common polar aprotic solvent. Acetonitrile is widely used as a ligand in inorganic chemistry,which is called MeCN for short. For example,the acetonitrile complex PdCl2 (MeCN) 2 can be prepared by heating the suspension of polymerized palladium chloride in acetonitrile.Acetonitrile is a popular cyclic voltammetric solvent due to its high dielectric constant.Acetonitrile is also a carbon dioxide raw material for organic synthesis.
It reacts with cyanogen chloride to obtain malonditrile.Acetonitrile is also used as a mobile phase separation molecule in column chromatography and more modern high-performance liquid chromatography. In the field of nuclear medicine,acetonitrile is used to synthesize positron radioactive drugs such as fluorodeoxyglucose.
In the process of synthesizing FDG,the evaporation of acetonitrile can take away the water in the reaction system;The amount of acetonitrile in the reaction system has a decisive influence on the synthesis efficiency of FDG and the drug quality;At the same time, acetonitrile is also used as the solvent and the matrix of the reaction system.In addition,acetonitrile water mixture (e.g. 85% v/v) is also used as the mobile phase for thin layer chromatographic analysis in the routine quality inspection of FDG.
