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Synthesis and Applications of THF

Views: 0     Author: Site Editor     Publish Time: 2023-03-06      Origin: Site

Tetrahydrofuran (THF) is an organic compound with the formula (CH2)4O. The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water-miscible organic liquid with low viscosity. It is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent.

THF Production

About 200000 t of tetrahydrofuran are produced annually. The most widely used industrial process involves the acid-catalyzed dehydration of 1,4-butanediol. The method is similar to the production of diethyl ether from ethanol. The butanediol is derived from condensation of acetylene with formaldehyde followed by hydrogenation. Du Pont developed a process for producing THF by oxidizing n-butane to crude maleic anhydride, followed by catalytic hydrogenation. A third major industrial route entails hydroformylation of allyl alcohol followed by hydrogenation to the butanediol.Tetrahydrofuran for sale -Yuanfarchemical

Tetrahydrofuran Applications

In the presence of strong acids, THF converts to a linear polymer called poly(tetramethylene ether) glycol (PTMEG), also known as PTMO, polytetramethylene oxide:

n C4H8O → −(CH2CH2CH2CH2O)n

This polymer is primarily used to make elastomeric polyurethane fibers like Spandex.

THF As a solvent

The other main application of THF is as an industrial solvent for PVC and in varnishes.It is an aprotic solvent with a dielectric constant of 7.6. It is a moderately polar solvent and can dissolve a wide range of nonpolar and polar chemical compounds.THF is water-miscible and can form solid clathrate hydrate structures with water at low temperatures.

In the laboratory, THF is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents. Although similar to diethyl ether, THF is a stronger base.Thus, while diethyl ether remains the solvent of choice for some reactions (e.g., Grignard reactions), THF fills that role in many others, where strong coordination is desirable and the precise properties of ethereal solvents such as these (alone and in mixtures and at various temperatures) allows fine-tuning modern chemical reactions.



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