Views: 1 Author: Site Editor Publish Time: 2022-07-20 Origin: Site
Tetrahydrofuran, also known as oxyheterocyclopentane and 1,4-epoxy butane, is a heterocyclic organic compound with the chemical formula of C4H8O. It belongs to the ether group. It is a completely hydrogenated product of furan. It is a colorless transparent liquid, soluble in water, ethanol, ether, acetone, benzene, etc. it is mainly used as a solvent, chemical synthesis intermediate, and analytical reagent.
Tetrahydrofuran is in the list of 2B carcinogens in the preliminary sorting reference of the list of carcinogens published by the international agency for research on cancer of the World Health Organization.
Chemical formula: C4H8O
Molecular weight: 72.107
CAS No.: 109-99-9
EINECS No.: 203-786-5
Melting point: -108.5 ℃
Boiling point: 66 ℃
Flash point: -14 ℃ (CC)
Refractive index: 1.465 (20 ℃)
Saturated vapor pressure: 19.3kpa (20 ℃)
Critical temperature: 268 ℃
Critical pressure: 5.19mpa
Ignition temperature: 321 ℃
Upper explosion limit (v/v): 11.8%
Lower explosive limit (v/v): 1.8%
Appearance: colorless liquid
Solubility: soluble in most organic solvents such as water, ethanol, ether, acetone and benzene.
Molar refractive index: 20.05
Molar volume (cm3/mol): 79.7
Isotonic specific volume (90.2k): 184.7
Surface tension (dyne/cm): 28.8
Polarizability (10-24 cm3): 7.94 
Reference value of hydrophobic parameter calculation (xlogp): None
Number of hydrogen bond donors: 0
Number of hydrogen bond receptors: 1
Number of rotatable chemical bonds: 0
Number of tautomers: None
Topological molecular polarity surface area: 9.2
Number of heavy atoms: 5
Surface charge: 0
Number of isotope atoms: 0
Determine the number of atomic structure centers: 0
Number of atomic stereocenters of uncertainty: 0
Determine the number of chemical bond conformation centers: 0
Number of indeterminate chemical bond conformation centers: 0
Number of covalent bond units: 1
1. Acute toxicity
Ld50:1650mg/kg (rat oral)
Lc50:21000ppm (rat inhalation, 3H)
Microbial mutagenicity: Escherichia coli 1 μ mol/L
Mice were given the lowest toxic dose (tdlo) of 2592mg/kg orally 6~17 days after pregnancy, resulting in musculoskeletal system development deformity.
Lc50:2160mg/l (96h) (black headed minnow)
Ic50:225mg/l (72h) (algae)
Miti-ii test showed that the initial concentration was 30ppm, the sludge concentration was 100ppm, and the degradation rate was 100% after 2 weeks.
3. Non biodegradable
In the air, when the concentration of hydroxyl radical is 5.00 × At 105 /cm3, the degradation half-life is 1D (theoretical).
Application of tetrahydrofuran
It is mainly used as solvent, intermediate of chemical synthesis and analytical reagent.
Respiratory protection: filter gas mask (half mask) should be worn when it may be exposed to its vapor. If necessary, it is recommended to wear self-contained breathing apparatus.
Eye protection: generally, special protection is not required, and safety glasses can be worn in case of high concentration contact.
Body protection: wear anti-static work clothes.
Hand protection: wear benzene and oil resistant gloves.
Others: smoking is strictly prohibited at the work site. Shower and change clothes after work. Pay attention to personal hygiene.