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Tetrahydrofuran's physical and chemical properties

Views: 1     Author: Site Editor     Publish Time: 2022-07-20      Origin: Site

Tetrahydrofuran, also known as oxyheterocyclopentane and 1,4-epoxy butane, is a heterocyclic organic compound with the chemical formula of C4H8O. It belongs to the ether group. It is a completely hydrogenated product of furan. It is a colorless transparent liquid, soluble in water, ethanol, ether, acetone, benzene, etc. it is mainly used as a solvent, chemical synthesis intermediate, and analytical reagent.

Tetrahydrofuran is in the list of 2B carcinogens in the preliminary sorting reference of the list of carcinogens published by the international agency for research on cancer of the World Health Organization.

Basic information of tetrahydrofuran

Chemical formula: C4H8O

Molecular weight: 72.107

CAS No.: 109-99-9

EINECS No.: 203-786-5

Physical and chemical properties of tetrahydrofuran

Density: 0.89g/cm3

Melting point: -108.5 ℃

Boiling point: 66 ℃

Flash point: -14 ℃ (CC)cheap tetrahydrofuran - YuanfarChemicals

Refractive index: 1.465 (20 ℃)

Saturated vapor pressure: 19.3kpa (20 ℃)

Critical temperature: 268 ℃

Critical pressure: 5.19mpa

Ignition temperature: 321 ℃

Upper explosion limit (v/v): 11.8%

Lower explosive limit (v/v): 1.8%

Appearance: colorless liquid

Solubility: soluble in most organic solvents such as water, ethanol, ether, acetone and benzene.

Molecular structure data of tetrahydrofuran

Molar refractive index: 20.05

Molar volume (cm3/mol): 79.7

Isotonic specific volume (90.2k): 184.7

Surface tension (dyne/cm): 28.8

Polarizability (10-24 cm3): 7.94 [1]

Calculated chemical data of tetrahydrofuran

Reference value of hydrophobic parameter calculation (xlogp): None

Number of hydrogen bond donors: 0

Number of hydrogen bond receptors: 1

Number of rotatable chemical bonds: 0

Number of tautomers: None

Topological molecular polarity surface area: 9.2

Number of heavy atoms: 5

Surface charge: 0

Complexity: 22.8

Number of isotope atoms: 0

Determine the number of atomic structure centers: 0

Number of atomic stereocenters of uncertainty: 0

Determine the number of chemical bond conformation centers: 0

Number of indeterminate chemical bond conformation centers: 0

Number of covalent bond units: 1

Toxicological data of tetrahydrofuran

1. Acute toxicity

Ld50:1650mg/kg (rat oral)

Lc50:21000ppm (rat inhalation, 3H)

2. Mutagenicity

Microbial mutagenicity: Escherichia coli 1 μ mol/L

3. Teratogenicity

Mice were given the lowest toxic dose (tdlo) of 2592mg/kg orally 6~17 days after pregnancy, resulting in musculoskeletal system development deformity.

Ecological data of tetrahydrofuran

1. Ecotoxicity

Lc50:2160mg/l (96h) (black headed minnow)

Ic50:225mg/l (72h) (algae)

2. Biodegradation

Miti-ii test showed that the initial concentration was 30ppm, the sludge concentration was 100ppm, and the degradation rate was 100% after 2 weeks.

3. Non biodegradable

In the air, when the concentration of hydroxyl radical is 5.00 × At 105 /cm3, the degradation half-life is 1D (theoretical).

Application of tetrahydrofuran

It is mainly used as solvent, intermediate of chemical synthesis and analytical reagent.

Protective measures for tetrahydrofuran

Respiratory protection: filter gas mask (half mask) should be worn when it may be exposed to its vapor. If necessary, it is recommended to wear self-contained breathing apparatus.

Eye protection: generally, special protection is not required, and safety glasses can be worn in case of high concentration contact.

Body protection: wear anti-static work clothes.

Hand protection: wear benzene and oil resistant gloves.

Others: smoking is strictly prohibited at the work site. Shower and change clothes after work. Pay attention to personal hygiene.

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